Mmmh thanks, but it doesn't seem to bring any changes to the characters. 
My game is 1280x720 and the screen resolution is 1920x1080 (Windows desktop resolution).
I am using your code from above to switch between mini/magni filters activated or not. My script is on the Space key (on release). 
Example:
 If condition Filter is true
  Execute script (1 -- see below)
else
  Execute script (2 -- see below)
end if
Toggle condition Filter
 Script  (1)
   game.MinificationFilter = 0
  game.MagnificationFilter = 0
 Script (2)
   game.MinificationFilter = 1
  game.MagnificationFilter = 1
 So everytime I press Space in the game, I should see a difference on my characters, shouldn't I? More or less pixels I mean. Or what am I doing wrong?